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盐酸达卡他韦 Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) 是HCV NS5A高度选择性抑制剂,EC50为9-50 pM。
中文名称:
N,N'-[[1,1'-联苯]-4,4'-二基双[1H-咪唑-5,2-二基-(2S)-2,1-吡咯烷二基[(1S)-1-(1-甲基乙基)-2-氧代-2,1-乙烷二基]]]二氨基甲酸二甲酯二盐酸盐
物化属性:
PSA:181.62000
LOGP:8.11060
[1]. Suzuki F, Sezaki H, Akuta N, Suzuki Y, Seko Y, Kawamura Y, Hosaka T, Kobayashi M, Saito S, Arase Y, Ikeda K, Kobayashi M, Mineta R, Watahiki S, Miyakawa Y, Kumada H.Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b.J Clin Virol. 2012 Aug;54(4):352-4. Epub 2012 Jun 1.
[2]. Jiang H, Zeng J, Kandoussi H, Liu Y, Wang X, Bifano M, Cojocaru L, Ryan J, Arnold ME.A sensitive and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of the novel hepatitis C NS5A inhibitor BMS-790052 (daclastasvir) in human plasma and urine.J Chromatogr A. 2012 Jul 6;1245:117-21. Epub 2012 May 14.
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