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RO5203648 HCl

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产品信息

产品名称：RO5203648 HCl	纯度：98% min
CAS NO：1043491-54-8	溶解度：
分子式：C₉H₈Cl₂N₂O	包装：可按客户要求包装
分子量：231.079	贮存：-20 ℃

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备注说明

RO5203648 is a TAAR1 partial agonist (Trace amine-associated receptor 1). RO5203648 showed high affinity and potency at TAAR1, high selectivity versus other targets, and favorable pharmacokinetic properties. RO5203648 increased the firing frequency of dopaminergic and serotonergic neurons in the ventral tegmental area and the dorsal raphe nucleus, respectively. RO5203648 demonstrated clear antipsychotic- and antidepressant-like activities as well as potential anxiolytic-like properties.

RO5203648 hydrochloride is a partial agonist of Trace amine-associated receptor 1 (TAAR1).

参考文献

1: Pei Y, Mortas P, Hoener MC, Canales JJ. Selective activation of the trace
amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents
cocaine-induced changes in brain reward thresholds. Prog Neuropsychopharmacol
Biol Psychiatry. 2015 Dec 3;63:70-5. doi: 10.1016/j.pnpbp.2015.05.014. Epub 2015
Jun 3. PubMed PMID: 26048337.