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NS13001

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产品信息

产品名称：NS13001	纯度：98% min
CAS NO：1063331-94-1	溶解度：
分子式：C₁₇H₁₆ClN₇	包装：可按客户要求包装
分子量：353.809	贮存：-20 ℃

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备注说明

NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.

参考文献

[1]. Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.