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GS-9451 Vedroprevir

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产品信息

产品名称：GS-9451 Vedroprevir	纯度：98% min
CAS NO：1098189-15-1	溶解度：
分子式：C₄₅H₆₀ClN₇O₉S	包装：可按客户要求包装
分子量：910.517	贮存：-20℃

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备注说明

Vedroprevir, also known as GS9451, is a selective hepatitis C virus (HCV) NS3 protease inhibitor in development for the treatment of genotype 1 (GT1) HCV infection. GS-9451 was less active in GT2a replicon cells (EC50 = 316 nM). GS-9451 retained wild-type activity against multiple classes of NS5B and NS5A inhibitor resistance mutations. GS-9451 showed good oral bioavailability in all three species tested.

中文别名:

N-[4-[4-氨基-6-(甲氧基甲基)-7-(4-吗啉基甲基)吡咯并[2,1-F][1,2,4]三嗪-5-基]-2-氟苯基]-N'-[2-氟-5-(三氟甲基)苯基]脲

参考文献

1: Meissner EG, Kohli A, Virtaneva K, Sturdevant D, Martens C, Porcella SF, McHutchison JG, Masur H, Kottilil S. Achieving sustained virologic response after interferon-free hepatitis C virus treatment correlates with hepatic interferon gene expression changes independent of cirrhosis. J Viral Hepat. 2016 Feb 3. doi: 10.1111/jvh.12510. [Epub ahead of print] PubMed PMID: 26840694.

2: Petersen T, Townsend K, Gordon LA, Sidharthan S, Silk R, Nelson A, Gross C, Calderón M, Proschan M, Osinusi A, Polis MA, Masur H, Kottilil S, Kohli A. High adherence to all-oral directly acting antiviral HCV therapy among an inner-city patient population in a phase 2a study. Hepatol Int. 2016 Mar;10(2):310-9. doi: 10.1007/s12072-015-9680-7. Epub 2015 Nov 26. PubMed PMID: 26612014; PubMed Central PMCID: PMC4778154.