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CRANAD-2

CRANAD-2 1193447-34-5
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产品信息
产品名称:CRANAD-2 纯度:98% min
CAS NO:1193447-34-5 溶解度:
分子式:C23H25BF2N2O2 包装:可按客户要求包装
分子量:410.265 贮存:-20℃
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备注说明

CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.

参考文献

1: Leung K. 5-(2E,4E)-5-(6-hydroxy-4-oxo-2-thioxo-1,2,3,4-tetrahydroxy-5

pyrimidinyl)-2,4-pentadienylidene-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione.

2012 Jul 01 [updated 2012 Oct 25]. Molecular Imaging and Contrast Agent Database

(MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information

(US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK109729/

PubMed PMID: 23115807.

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