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HA155 (Autotaxin Inhibitor IV), a boronic acid-based compound, inhibits autotaxin with IC50 of 5.7 nM by selectively binding to its catalytic threonine.
1: Katsamakas S, Papadopoulos AG, Hadjipavlou-Litina D. Boronic Acid Group: A
Cumbersome False Negative Case in the Process of Drug Design. Molecules. 2016 Sep
7;21(9). pii: E1185. doi: 10.3390/molecules21091185. PubMed PMID: 27617984.
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