0576-88813233
kb NB 142-70 是一种有效的 PKD 抑制剂,对 PKD1,PKD2 和 PKD3 的 IC50 值分别为 28.3 nM,58.7 nM 和 53.2 nM;kb NB 142-70 同时具有抗肿瘤活性。
中文名称:
3,4-二氢-9-羟基-[1]苯并噻吩并[2,3-F]-1,4-硫氮杂卓-5(2H)-酮
物化属性:
熔点:235-238℃ (decomposition) (water dichloromethane )
[1]. Lavalle CR, et al. Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. BMC Chem Biol. 2010 May 5;10:5.
[2]. James Sinnett-Smith, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15; 306(10): C961-C971.
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