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产品描述:
Ledipasvir(GS5885)是一种HCV NS5A polymerase抑制剂,用于治疗丙型肝炎病毒感染。
靶点:
HCV
物化属性:
密度:1.42±0.1 (20 oC 760 Torr)
熔点:微溶 (5.9E-5 g/L) (25 oC)
[1]. Link JO, et al. Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection. J Med Chem. 2014 Mar 13;57(5):2033-46
[2]. Hernandez D, et al. Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors. J Clin Virol. 2013 May;57(1):13-8.
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