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比马前列素异丙酯

比马前列素异丙酯 130209-76-6
规格 价格 库存 数量
100mg ¥4500 In-Stock
50mg ¥3000 In-Stock
10mg ¥1000 In-Stock
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产品信息
产品名称:比马前列素异丙酯 纯度:98%min
CAS NO:130209-76-6 溶解度:Soluble in DMSO
分子式:C26H38O5 包装:可按客户要求包装。
分子量:430.58 贮存:Store at -20℃ 3 years
质量控制
COA
备注说明
比马前列素异丙酯Bimatoprost isopropyl ester ( 7-phenyl trinor PGF2α N-ethyl amide )is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.1 The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost.2 This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.3 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost.4 At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.4
参考文献

1. Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et Biophysica Acta 1483, 285-293 (2000). 2. Woodward, D.F., Krauss, A.H.P., Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Survey of Ophthalmology 45, S337-S345 (2001).

3. Resul, B., Stjernschantz, J., Selén, G., et al. Structure-activity relationships and receptor profiles of some ocular hypotensive prostanoids. Survey of Ophthalmology 41, S47-S52 (1997).

4. Maxey, K.M., Johnson, J., Camras, C.B., et al. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Survey of Ophthalmology 47(4), 34-40 (2002).

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