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阿特珠单抗 Atezolizumab

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产品信息

产品名称：阿特珠单抗 Atezolizumab	纯度：99% min
CAS NO：1380723-44-3	溶解度：
分子式：C₆₄₄₆H₉₉₀₂N₁₇₀₆O₁₉₉₈S₄₂	包装：可按客户要求包装
分子量：144,612.59 g/mol	贮存：-20℃

质量控制

备注说明

Atezolizumab blocks the interaction of PD-L1 with programmed cell death protein 1 (PD-1) and CD80 receptors (B7-1Rs). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer.Inhibition of PD-L1 by atezolizumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as "immune checkpoint inhibition."

For some cancers (notably bladder) the probability of benefit is related to PD-L1 expression, but most cancers with PD-L1 expression still do not respond, and many (about 15%) without PD-L1 expression do respond.

中文别名:

阿特朱单抗; 达雷木单抗

参考文献

[1]. Cha E, et al. PD-L1 inhibition with MPDL3280A for solid tumors. Semin Oncol. 2015 Jun;42(3):484-7.