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瑞斯西丁素 Ristocetin A

瑞斯西丁素 Ristocetin A 1404-55-3
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产品信息
产品名称:瑞斯西丁素 Ristocetin A 纯度:98% min
CAS NO:1404-55-3 溶解度:Soluble in DMSO
分子式:C95H110N8O44 包装:可按客户要求包装
分子量:2067.92 贮存:-20℃
质量控制
备注说明

Ristocetin is an antibiotic, obtained from Amycolatopsis lurida, previously used to treat staphylococcal infections. It is no longer used clinically because it caused thrombocytopenia and platelet agglutination. It is now used solely to assay those functions in vitro in the diagnosis of conditions such as von Willebrand disease (vWD) and Bernard-Soulier syndrome. Platelet agglutination caused by ristocetin can occur only in the presence of von Willebrand factor multimers, so if ristocetin is added to blood lacking the factor (or its receptor—see below), the platelets will not clump.

 

中文别名:

瑞斯托霉素硫酸盐; 瑞斯托菌素; 利托菌素; 瑞斯西丁素; 瑞斯托菌素A; 瑞斯托霉素;

 

物化属性:

折射率:1.783

储存条件:2-8°C

PSA:816.22000

LOGP:-3.12800

 

参考文献

1: Stufano F, Lawrie AS, La Marca S, Berbenni C, Baronciani L, Peyvandi F. A two-centre comparative evaluation of new automated assays for von Willebrand factor ristocetin cofactor activity and antigen. Haemophilia. 2014 Jan;20(1):147-53. doi: 10.1111/hae.12264. Epub 2013 Sep 12. PubMed PMID: 24028703.

2: Wagdy HA, Hanafi RS, El-Nashar RM, Aboul-Enein HY. Enantiomeric separation of underivatized amino acids: predictability of chiral recognition on ristocetin a chiral stationary phase. Chirality. 2014 Mar;26(3):132-5. doi: 10.1002/chir.22291. Epub 2014 Jan 22. PubMed PMID: 24453195.

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