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产品描述:
Miriplatin是cisplatin的衍生物,含有作为载体配体的豆蔻酸盐。它是新型亲脂的铂络合物,用于治疗肝细胞癌。
物化属性:
PSA:132.30000
LOGP:8.48790
[1]. Kishimoto S, et al. Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration. Biol Pharm Bull. 2000 Mar;23(3):344-8.
[2]. Hanada M, et al. Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis. Cancer Chemother Pharmacol. 2009 Aug;64(3):473-83.
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