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Triapine(3-AP) 是一种核糖核苷酸还原酶 (ribonucleotide reductase,RR) 的 M2 亚基抑制剂,是有效的放射致敏剂。
中文别名:
3-氨基吡啶-2-甲醛氨基硫脲腙;
2-[(3-氨基吡啶-2-基)亚甲基]氨基硫脲
物化属性:
密度:1.46
沸点:435.961°C at 760 mmHg
折射率:1.72
闪光点:217.462°C
颜色:white to light brown
[1]. Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e475-81.
[2]. Yalowich JC, et al. The anticancer thiosemicarbazones Dp44mT and Triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα. Biochem Pharmacol. 2012 Jul 1;84(1):52-8.
[3]. Whitnall M, et al. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6.
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