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匹杉琼Prasugrel (PCR 4099) 是ADP受体抑制剂,能通过不可逆的与P2Y12受体结合降低血小板的聚集。
中文别名:
6,9-二[(2-氨乙基)氨基]苯并[g]异喹啉-5,10-二酮; 拓扑异构酶Ⅱ抑制剂; PIXANTRONEBBR 2778匹杉琼; 匹克生琼; 匹杉琼; 马来酸匹杉琼; 匹杉琼二马来酸盐
物化属性:
密度:1.405
沸点:650°Cat760mmHg
折射率:1.728
闪光点:346.9°C
PSA:123.13000
LOGP:2.14480
[1]. Beeharry N, et al. Pixantrone induces cell death through mitotic perturbations and subsequent aberrant cell divisions. Cancer Biol Ther. 2015;16(9):1397-406.
[2]. Hasinoff BB, et al. Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform. J Pharmacol Exp Ther. 2016 Feb;356(2):397-409.
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