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CYM5520

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产品信息

产品名称：CYM5520	纯度：98% min
CAS NO：1449747-00-5	溶解度：
分子式：C₂₁H₁₉N₃O₂	包装：可按客户要求包装
分子量：345.394	贮存：-20℃

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备注说明

CYM5520 is a pyrrolyl ketone derivative that acts as a potent, selective, allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2; EC50 = 480 nM) that does not replace native ligand and its binding is not competitive with JTE-013. The compound CYM-5520 does not show any agonsit activity towards S1PR1, S1PR3, S1PR4 or S1PR5. It acts as a full agonist for both wild type and triple mutant S1PR2 (EC50 = 1.6 and 1.5 µM, respectively).

参考文献

1: Satsu H, Schaeffer MT, Guerrero M, Saldana A, Eberhart C, Hodder P, Cayanan C, Schürer S, Bhhatarai B, Roberts E, Rosen H, Brown SJ. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg Med Chem. 2013 Sep 1;21(17):5373-82. doi: 10.1016/j.bmc.2013.06.012. Epub 2013 Jun 15. PubMed PMID: 23849205; PubMed Central PMCID: PMC3786410.