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利克飞龙 Licofelone

利克飞龙 Licofelone 156897-06-2
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产品信息
产品名称:利克飞龙 Licofelone 纯度:99% min
CAS NO:156897-06-2 溶解度:Soluble in DMSO
分子式:C23H22ClNO2 包装:可按客户要求包装
分子量:379.879 贮存:-20℃
质量控制
备注说明

Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis and which is under development by Merckle GmbH with partners Alfa Wassermann and Lacer.

Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-LOX may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both. It has passed the phase III trials.

 

文别名:

核黄素磷酸钠盐; 利克飞龙; 2-[2-(4-氯苯基)-6,6-二甲基-1-苯基-5,7-二氢吡咯烷嗪-3-基]乙酸

 

物化属性:

外观与形状:淡黄色固体

密度:1.23

熔点:162-163°C

沸点:539.7 °C at 760 mmHg

折射率:1.626

闪光点:280.2 °C

储存条件:-20°C Freezer

PSA:42.23000

LOGP:5.68490

 

参考文献

1: Payandemehr B, Khoshneviszadeh M, Varastehmoradi B, Gholizadeh R, Bahremand T, Attar H, Bahremand A, Dehpour AR. A COX/5-LOX Inhibitor Licofelone Revealed Anticonvulsant Properties Through iNOS Diminution in Mice. Neurochem Res. 2015 Sep;40(9):1819-28. doi: 10.1007/s11064-015-1669-z. Epub 2015 Jul 28. PubMed PMID: 26216049.

2: Balansky R, Ganchev G, Iltcheva M, Nikolov M, Maestra SL, Micale RT, D'Agostini F, Steele VE, De Flora S. Modulation by licofelone and celecoxib of experimentally induced cancer and preneoplastic lesions in mice exposed to cigarette smoke. Curr Cancer Drug Targets. 2015;15(3):188-95. PubMed PMID: 25687474.

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