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坎格雷洛 Cangrelor

坎格雷洛 Cangrelor 163706-06-7
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产品信息
产品名称:坎格雷洛 Cangrelor 纯度:99% min
CAS NO:163706-06-7 溶解度:Soluble in DMSO
分子式:C17H25Cl2F3N5O12P3S2 包装:可按客户要求包装
分子量:776.359 贮存:-20℃
质量控制
备注说明

Cangrelor is a P2Y12 inhibitor, and was approved in June 2015 as an antiplatelet drug for intravenous application. Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. It is a modified ATP derivative stable to enzymatic degradation. It does not require metabolic conversion to an active metabolite. This allows cangrelor's immediate effect after infusion, and the therapeutic effects can be maintained with continuous infusion.

 

产品名称:

MCOPPB;

1-[1-(1-甲基环辛基)-4-哌啶基]-2-[(3R)-3-哌啶基]-1H-苯并咪唑

 




参考文献

1: Judge HM, Buckland RJ, Jakubowski JA, Storey RF. Cangrelor inhibits the binding of the active metabolites of clopidogrel and prasugrel to P2Y(12) receptors in vitro. Platelets. 2015 Aug 13:1-5. [Epub ahead of print] PubMed PMID: 26270719.

2: Keating GM. Cangrelor: A Review in Percutaneous Coronary Intervention. Drugs. 2015 Aug;75(12):1425-34. doi: 10.1007/s40265-015-0445-3. PubMed PMID: 26201463.

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