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OSMI-1

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产品信息

产品名称：OSMI-1	纯度：98% min
CAS NO：1681056-61-0	溶解度：
分子式：C₂₈H₂₅N₃O₆S₂	包装：可按客户要求包装
分子量：563.645	贮存：-20 ℃

质量控制

备注说明

OSMI-1 is a quinolinone-6-sulfonamide that inhibits O-GlcNAc transferase (OGT; IC50 = 2.7 μM) in vitro.[1] It is cell permeable and inhibits global O-GlcNAcylation in a dose-dependent manner in CHO cells. OSMI-1 induces a mass shift of nucleoporin62 (Nup62) that corresponds to the loss of O-GlcNAc residues and decreases levels of cellular O-GlcNAcase (OGA). OSMI-1 (50 μM) also causes a 50% decrease in CHO cell viability after 24 hours.

参考文献

[1]. Ortiz-Meoz, R.F., Jiang, J., Lazarus, M.B., et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 10(6), 1392-1397 (2015).