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咪达那新Imidafenacin(KRP-197; ONO-8025)是一种有效的和选择性的M3受体抑制剂,Kb值为0.317nM,对M2受体Kb值稍弱。
中文别名:
4-(2-甲基-1H-咪唑-1-基)-2,2-二苯基丁酰胺;
2-Methyl-α,α-diphenyl-1H-iMidazole-1-butanaMide
物化属性:
密度:1.12
沸点:579.7°Cat760mmHg
折射率:1.602
闪光点:304.4°C
PSA:61.90000
LOGP:4.20290
[1]. Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7(6):1151-61.
[2]. Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1095-102.
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