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伐瑞拉迪Varespladib (LY315920) 是高活性的人非胰腺分泌磷脂酶A2(sPLA)选择性抑制剂,IC50为7 nM。
中文别名:
[[3-(氨基氧代乙酰基)-2-乙基-1-(苯基甲基)-1H-吲哚-4-基]氧基]乙酸;
伐瑞拉地
物化属性:
沸点:667.9°C at 760 mmHg
闪光点:357.7°C
储存条件:-20°C
PSA:111.62000
LOGP:3.08370
[1]. Draheim SE, et al. Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides. J Med Chem. 1996 Dec 20;39(26):5159-75.
[2]. Snyder DW, et al. Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther. 1999 Mar;288(3):1117-24.
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