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Ciproxifan(FUB-359)是高活性的H3受体拮抗剂,IC50为9.2 nM,对其它亚型受体的亲和力较低。
中文别名:
环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯基]甲酮; 环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯
物化属性:
密度:1.231
沸点:526.9°C at 760 mmHg
折射率:1.613
闪光点:272.5°C
[1]. Motawaj M, Arrang JM. Ciproxifan, a histamine H?-receptor antagonist?/?inverse agonist, modulates methamphetamine-induced sensitization in mice. Eur J Neurosci. 2011 Apr;33(7):1197-204. doi: 10.1111/j.1460-9568.2011.07618.x.
[2]. Bardgett ME, et al. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72.
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