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齐泊腾坦Zibotentan (ZD4054)是口服活性的内皮素A(ETA)受体特异性拮抗剂,IC50为21 nM。
物化属性:
密度:1.423
沸点:636.996 °C at 760 mmHg
闪光点:339.043 °C
PSA:141.37000
LOGP:3.86020
[1]. Clarkson-Jones JA, Kenyon AS, Kemp J, Lenz EM, Oliver SD, Swaisland H.,Disposition and metabolism of the specific endothelin A receptor antagonist zibotentan (ZD4054) in healthy volunteers.,Xenobiotica. 2012 Apr;42(4):363-71. Epub 2011 Oct 20.
[2]. Li J, Liu Y, Qian J, Wu L, Kemp J, Nii M, Tomkinson H, Zuo Y, Ranson M, Usami M.,Single- and multiple-dose pharmacokinetics, safety and tolerability of zibotentan (ZD4054) in Chinese men with advanced solid tumors.,Cancer Chemother Pharmacol. 2012 Jul;70(1):57-63. Epub 2012 May 22.
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