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埃博霉素 D,Epothilone D (KOS 862) 是有效的微管稳定剂。
中文别名:
埃博霉素D; 埃坡霉素D; 埃博霉素D; 埃坡西龙 D; 埃博霉素 D
物化属性:
密度:1.084
熔点:63-66°C
沸点:663.7°Cat760mmHg
折射率:1.522
闪光点:355.2°C
比旋光度:D22 -61.3° (c = 2.5 in methanol)
储存条件:-20°C Freezer
PSA:124.96000
LOGP:4.87620
[1]. Konner J, et al. Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma. Invest New Drugs. 2012 Dec;30(6):2294-302.
[2]. Brunden KR, et al. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci. 2010 Oct 13;30(41):13861-6.
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