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DAPT是 γ-分泌酶 (γ-secretase) 抑制剂,抑制总 Aβ 和 Aβ42 的 IC50 分别为 115 和 200 nM。
物化属性:
外观与形状:白色固体
密度:1.213
沸点:612.2°C at 760 mmHg
折射率:1.534
闪光点:324.1°C
储存条件:2-8°C
颜色:white
PSA:84.50000
LOGP:3.99300
[1]. Dovey HF, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81.
[2]. Zhou JX, et al. γ-secretase inhibition combined with cisplatin enhances apoptosis of nasopharyngeal carcinoma cells.Exp Ther Med. 2012 Feb;3(2):357-361.
[3]. Li S, et al. DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and nuclear factor κB in rats. Neurol Sci. 2012 Dec;33(6):1257-64.
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