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LY-404187

LY-404187 211311-95-4
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产品信息
产品名称:LY-404187 纯度:98% min
CAS NO:211311-95-4 溶解度:Soluble in DMSO
分子式:C19H22N2O2S 包装:可按客户要求包装
分子量:342.455 贮存:-20℃
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备注说明

LY-404187 is an ampakine, AMPA receptor potentiator. LY-404187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting antidepressant action as well as having possible application in the treatment of schizophrenia, Parkinson's disease and ADHD. These effects appear to be mediated through multiple mechanisms of action secondary to AMPA receptor potentiation, with a prominent effect seen in research being increased levels of BDNF in the brain.

 

中文名称:

N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺

 

 

参考文献

1: Andreasen JT, Fitzpatrick CM, Larsen M, Skovgaard L, Nielsen SD, Clausen RP, Troelsen K, Pickering DS. Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action. Brain Res. 2015 Mar 19;1601:117-26. doi: 10.1016/j.brainres.2015.01.001. Epub 2015 Jan 8. PubMed PMID: 25578259.

2: Song B, Lee S, Choi S. LY404187, a potentiator of AMPARs, enhances both the amplitude and 1/CV2 of AMPA EPSCs but not NMDA EPSCs at CA3-CA1 synapses in the hippocampus of neonatal rats. Neurosci Lett. 2012 Dec 7;531(2):193-7. doi: 10.1016/j.neulet.2012.10.020. Epub 2012 Oct 26. PubMed PMID: 23103715.

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