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氧嗪酸钾Potassium oxonate 是尿酸酶抑制剂,能抑制5-FU磷酸化为5-fluorouridine-5'-monophosphate。
中文别名:
氧氢酸钾; 氧嗪酸钾(OXO); 草酰钾; 1,4,5,6-四氢-4,6-二氧-1,3,5-三嗪-2-羧酸钾; 4,6-二羟基-1,3,5-噻嗪-2-羧酸钾盐; 奥替拉西钾
物化属性:
外观与形状:灰白色固体
熔点:300℃
PSA:118.74000
LOGP:-3.17830
[1]. Shirasaka T, et al. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 1993 Sep 1;53(17):4004-9.
[2]. Eraranta A, et al. Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens. 2008 Aug;26(8):1661-8.
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