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Telomestatin

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产品信息

产品名称：Telomestatin	纯度：99% min
CAS NO：265114-54-3	溶解度：Soluble in DMSO
分子式：C₂₆H₁₄N₈O₇S	包装：可按客户要求包装
分子量：582.504	贮存：-20℃

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备注说明

Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of the cancer cells. It was first isolated from the bacteria Streptomyces anulatus. Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.

参考文献

1: Abraham Punnoose J, Ma Y, Li Y, Sakuma M, Mandal S, Nagasawa K, Mao H. Adaptive and Specific Recognition of Telomeric G-quadruplexes via Polyvalency Induced Unstacking of Binding Units. J Am Chem Soc. 2017 May 15. doi: 10.1021/jacs.7b00607. [Epub ahead of print] PubMed PMID: 28505453.

2: Maleki P, Ma Y, Iida K, Nagasawa K, Balci H. A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions. Nucleic Acids Res. 2017 Jan 9;45(1):288-295. doi: 10.1093/nar/gkw1090. Epub 2016 Nov 29. PubMed PMID: 27899628; PubMed Central PMCID: PMC5224478.