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DMAB-anabaseine

DMAB-anabaseine 32013-69-7
规格 价格 库存 数量
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产品信息
产品名称:DMAB-anabaseine 纯度:99% min
CAS NO:32013-69-7 溶解度:Soluble in DMSO
分子式:C19H23Cl2N3 包装:可按客户要求包装
分子量:364.312 贮存:-20℃
质量控制
备注说明

GTS-21, also known as DMBX-A, is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent. Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease, nicotine dependence, and, most significantly, for schizophrenia.

 

中文名称:

(E)-N,N-二甲基-4-((2-(吡啶-3-基)-5,6-二氢吡啶-3(4h)-亚基)甲基)苯胺


物化属性:

沸点:516.7°Cat760mmHg

闪光点:266.3°C

PSA:28.49000

LOGP:4.85370

 

参考文献

1: Yue Y, Liu R, Cheng W, Hu Y, Li J, Pan X, Peng J, Zhang P. GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor. Int Immunopharmacol. 2015 Oct 17. pii: S1567-5769(15)30138-7. doi: 10.1016/j.intimp.2015.10.005. [Epub ahead of print] PubMed PMID: 26490221.

2: Kong FJ, Ma LL, Zhang HH, Zhou JQ. Alpha 7 nicotinic acetylcholine receptor agonist GTS-21 mitigates isoflurane-induced cognitive impairment in aged rats. J Surg Res. 2015 Mar;194(1):255-61. doi: 10.1016/j.jss.2014.09.043. Epub 2014 Oct 5. PubMed PMID: 25450597.

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