0576-88813233
阿伐那非Avanafil(TA-1790)是高活性PDE-5抑制剂,IC50为5.2 nM,对PDE1,PDE6和PDE11活性较低。
中文别名:
4-[(3-氯-4-甲氧基苄基)氨基]-2-[2-(羟甲基)-1-吡咯烷基]-N-(2-嘧啶基甲基)-5-嘧啶甲磺酰胺
物化属性:
外观与形状:白色固体
密度:1.372g/cm3
熔点:150-152 °C
折射率:1.651
PSA:125.39000
LOGP:2.96070
[1]. Kotera J, et al. Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction. J Urol. 2012 Aug;188(2):668-74.
[2]. Wang R, et al. Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability. J Sex Med. 2012 Aug;9(8):2122-9.
版权所有 Copyright(C) 2018-2022 台州市科瑞生物技术有限公司