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诺孕酯 norgestimate

诺孕酯 norgestimate 35189-28-7
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产品信息
产品名称:诺孕酯 norgestimate 纯度:98% min
CAS NO:35189-28-7 溶解度:Soluble in DMSO
分子式:C23H31NO3 包装:可按客户要求包装
分子量:369.497 贮存:-20℃
质量控制
备注说明

Norgestimate is an acetylated progestinused in combination with ethinyl estradiol as an oral contraceptive. It acts as a prodrug to norelgestromin (17-deacetylnorgestimate or levonorgestrel 3-oxime), the primary active metabolite, and levonorgestrel (deacetylation of norgestimate occurs in the intestines and the liver). Unlike levonorgestrel, norgestimate shows high selectivity for the progesterone receptor and low androgenic action due to a large drug-induced elevation in the level of sex hormone-binding globulin (SHBG) (which preferentially binds androgens and thus inhibits their action). In accordance, clinical trials have observed minimal androgenic side effects. Norgestimate and its metabolites themselves, unlike many other progestins, do not bind to SHBG.

 

中文别名:

诺孕酪炔; 诺肟酯


物化属性:

外观与形状:白色结晶固体

密度:1.22

熔点:216℃

沸点:497.9°Cat760mmHg

折射率:1.611

闪光点:254.9°C

PSA:58.89000

LOGP:4.71450

参考文献

1: Curran MP, Wagstaff AJ. Spotlight on estradiol and norgestimate as hormone replacement therapy in postmenopausal women. Treat Endocrinol. 2002;1(2):127-9. Review. PubMed PMID: 15765628.

2: Curran MP, Wagstaff AJ. Estradiol and norgestimate: a review of their combined use as hormone replacement therapy in postmenopausal women. Drugs Aging. 2001;18(11):863-85. Review. PubMed PMID: 11772126.


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