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鲁拉西酮 Lurasidone

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产品信息

产品名称：鲁拉西酮 Lurasidone	纯度：99% min
CAS NO：367514-87-2	溶解度：DMSO : 20.83 mg/mL (42.28 mM)
分子式：C₂₈H₃₆N₄O₂S	包装：可按客户要求包装
分子量：492.676	贮存：-20℃

质量控制

备注说明

Lurasidone is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.

物化属性:

密度：1.273

沸点：623.4°C at 760 mmHg

折射率：1.636

闪光点：330.8°C

解离常数：pKa1 = 1.96 (imine); pKa2 = 8.50 (amine) (est)

参考文献

[1]. Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81.

[2]. Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4): 931-937.