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吡仑帕奈 PeraMpanel

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产品信息

产品名称：吡仑帕奈 PeraMpanel	纯度：98% min
CAS NO：380917-97-5	溶解度：
分子式：C₂₃H₁₅N₃O	包装：可按客户要求包装
分子量：349.385	贮存：-20℃

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备注说明

Perampanel is a selective noncompetitive antagonist of AMPA receptors, the major subtype of ionotropic glutamate receptors. Perampanel was found to be effective in the treatment of refractory partial-onset seizures in three pivotal (Phase 3) clinical trials and has been approved for marketing under the brand name Fycompa by the European Medicines Agency. The drug is currently approved, for the control of partial-onset seizures, in those of both sexes who suffer from epilepsy and who are 12 years of age and older. Perampanel is discontinued.

参考文献

1: Trinka E, Steinhoff BJ, Nikanorova M, Brodie MJ. Perampanel for focal epilepsy: insights from early clinical experience. Acta Neurol Scand. 2016 Mar;133(3):160-72. doi: 10.1111/ane.12529. Review. PubMed PMID: 26506904; PubMed Central PMCID: PMC4738453.

2: Glauser T, Laurenza A, Yang H, Williams B, Ma T, Fain R. Efficacy and tolerability of adjunct perampanel based on number of antiepileptic drugs at baseline and baseline predictors of efficacy: A phase III post-hoc analysis. Epilepsy Res. 2016 Jan;119:34-40. doi: 10.1016/j.eplepsyres.2015.11.014. PubMed PMID: 26656783.