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产品描述:
PK11000通过共价半胱氨酸修饰稳定野生型和突变型p53的DBD,而又不影响DNA结合,并且能有效诱导细胞死亡。
中文别名:
5-氯-2-(甲基磺酰基)嘧啶-4-羧酸
[1]. Bauer MR, et al. 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5271-80.
[2]. Synnott NC, et al. Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007. Cancer Lett. 2018 Feb 1;414:99-106
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