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Tandutinib(MLN518, CT53518)坦度替尼是FLT3拮抗剂,IC50为0.22 μM,还抑制PDGFR 和c-Kit。
物化性质
密度:1.213 g/cm3
沸点:769.5ºC at 760 mmHg
熔点:177-178°C
闪点:419.2ºC
折射率:1.61
[1]. Kelly LM, et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell, 2002, 1(5), 421-432.
[2]. Griswold IJ, et al. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood, 2004, 104(9), 2912-2918.
[3]. Schittenhelm MM, et al. The FLT3 inhibitor tandutinib (formerly MLN518) has sequence-independent synergistic effects with cytarabine and daunorubicin. Cell Cycle, 2009, 8(16), 2621-2630.
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