0576-88813233
二对甲苯磺酸拉帕替尼Lapatinib ditosylate(GW-572016 ditosylate)是EGFR和ErbB2抑制剂,IC50分别为10.8和9.2 nM。
物化属性
外观与形状:黄色固体
密度:1.381
熔点:240-2420C
沸点:750.7°C at 760 mmHg
闪光点:407.8°C
储存条件:
-20°C Freezer, Under Inert Atmosphere
PSA:240.23000
LOGP:12.32880
[1]. Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94.
[2]. O'Neill F, et al. Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines. Mol Cancer. 2012 Jun 18;11(1):41.
[3]. Eryilmaz U, et al. S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. PLoS One. 2015 Dec 18;10(12):e0145418.
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