0576-88813233
PD0325901是选择性,可渗透细胞的 MEK 抑制剂, IC50为0.33 nM。
物化属性:
密度:1.818
熔点:112-114 °C
折射率:1.645
PSA:90.82000
LOGP:2.93060
[1]. Barrett SD, et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6501-4.
[2]. Henderson YC, et al. MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo. Mol Cancer Ther. 2010 Jul;9(7):1968-76.
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