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PCNA-I 1

PCNA-I 1 444930-42-1
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产品信息
产品名称:PCNA-I 1 纯度:98% min
CAS NO:444930-42-1 溶解度:
分子式:C17H14N2O2S 包装:可按客户要求包装
分子量:310.37 贮存:-20°C
质量控制
备注说明

PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 µM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 µM) over non-transformed cells (IC50s = 0.99-2 µM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.

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