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VPC-23019

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产品信息

产品名称：VPC-23019	纯度：98% min
CAS NO：449173-19-7	溶解度：
分子式：C₁₇H₂₉N₂O₅P	包装：可按客户要求包装
分子量：372.396	贮存：-20℃

质量控制

备注说明

VPC-23019 is a sphingosine-1-phosphate receptor antagonist. VPC-23019 acts as a competitive antagonist at both S1P1 and S1P3 receptors (pKis = 7.86 and 5.93, respectively). VPC-23019 can inhibit S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells.

参考文献

[1]. Arthur C.M. Mulders, Mariëlle C. Hendriks-Balk, Marie-Jeanne Mathy, et al. Sphingosine Kinase-dependent Activation of Endothelial Nitric Oxide Synthase by Angiotensin II. Arterioscler Thromb Vasc Biol., 2006, 26:2043-2048.
[2]. Isao Inoki, Noriko Takuwa, Naotoshi Sugimoto, et al. Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor. Biochemical and Biophysical Research Communications, 2006, 346: 293-300.