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长春新碱 Vincristine

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产品信息

产品名称：长春新碱 Vincristine	纯度：98% min
CAS NO：57-22-7	溶解度：Soluble in DMSO
分子式：C₄₆H₅₆N₄O₁₀	包装：可按客户要求包装。
分子量：824.958	贮存：-20℃

质量控制

备注说明

Vincristine is a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.

物化属性:

外观与形状：固体

密度：1.4

熔点：211-216℃

折射率：1.677

颜色：Blades from methanol

PSA：171.17000

LOGP：4.09420

参考文献

1: Harrison TS, Lyseng-Williamson KA. Vincristine sulfate liposome injection: a guide to its use in refractory or relapsed acute lymphoblastic leukemia. BioDrugs. 2013 Feb;27(1):69-74. doi: 10.1007/s40259-012-0002-5. Review. PubMed PMID: 23329395.

2: Silverman JA, Deitcher SR. MarqiboÂ® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine. Cancer Chemother Pharmacol. 2013 Mar;71(3):555-64. doi: 10.1007/s00280-012-2042-4. Epub 2012 Dec 5. Review. PubMed PMID: 23212117; PubMed Central PMCID: PMC3579462.