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氨己烯酸 Vigabatrin

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产品信息

产品名称：氨己烯酸 Vigabatrin	纯度：98% min
CAS NO：60643-86-9	溶解度：H2O: ≥ 52 mg/mL
分子式：C₆H₁₁NO₂	包装：可按客户要求包装
分子量：129.15	贮存：-20℃

质量控制

备注说明

Vigabatrin, also known as gamma-vinyl-GABA, is an antiepileptic drug that inhibits the breakdown of γ-aminobutyric acid (GABA) by acting as a suicide inhibitor of GABA transaminase (GABA-T). It is a structural analog of GABA, but does not bind to GABA receptors. Vigabatrin is an irreversible suicide inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the catabolism of GABA, which increases the level of GABA in the brain. Vigabatrin is a racemic compound, and its [S]-enantiomer is pharmacologically active.

中文别名:

4-氨基-5-己烯酸; 氨乙烯酸; 氨已烯酸

物化属性:

PSA：63.32000

LOGP：1.06480

参考文献

1: Nøhr MK, Frølund S, Holm R, Nielsen CU. Pharmacokinetic aspects of the anti-epileptic drug substance vigabatrin: focus on transporter interactions. Ther Deliv. 2014 Aug;5(8):927-42. doi: 10.4155/tde.14.55. Review. PubMed PMID: 25337649.

2: Hemming K, Maguire MJ, Hutton JL, Marson AG. Vigabatrin for refractory partial epilepsy. Cochrane Database Syst Rev. 2013 Jan 31;1:CD007302. doi: 10.1002/14651858.CD007302.pub2. Review. PubMed PMID: 23440814.