0576-88813233
阿普司特Apremilast 是一种磷酸二酯酶 4 (PDE4) 抑制剂,IC50 为 74 nM。
中文别名:
匹米斯特;
S)-2-[1-(3-乙氧基-4-甲氧基苯基)-2-甲磺酰基乙基]-4-乙酰基氨基异吲哚啉-1,3-二酮
物化属性:
PSA:127.46000
LOGP:3.52590
[1]. Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249.
[2]. Chen LG, et al. Determination of Apremilast in Rat Plasma by UPLC-MS-MS and Its Application to a Pharmacokinetic Study. J Chromatogr Sci. 2016 Sep;54(8):1336-40.
版权所有 Copyright(C) 2018-2022 台州市科瑞生物技术有限公司