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Ki-20227是CSF1R抑制剂,IC50为2 nM,对VEGFR2的IC50为12 nM,对c-Kit/PDGFRβ的IC50则为451/217 nM。
中文名称:
N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲
物化属性:
密度:1.327
沸点:621.788 °C at 760 mmHg
闪光点:329.846 °C
PSA:132.07000
LOGP:5.85600
[1]. Ohno H, et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther. 2006 Nov;5(11):2634-43.
[2]. Ohno H, et al. The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model. Eur J Immunol. 2008 Jan;38(1):283-91.
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