Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosuppressant activity. Cyclosporin B is a derivative of cyclosporin A that exhibits significantly less immunosuppressive activity. Cyclosporin B displays antiviral properties, inhibiting entry of hepatitis B into hepatocytes. Cyclosporin B also inhibits RANKL-induced TRAP phosphatase activity, inducing apoptosis in osteoclasts.
物化属性:
外观与形状:无定形白色固体
密度:1.019
熔点:149-152 oC
沸点:1289.7 °C at 760 mmHg
折射率:1.468
闪光点:733.8 °C
PSA:278.80000
LOGP:3.75940