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尼洛替尼Nilotinib是一种口服可用的具有抗肿瘤活性的 Bcr-Abl 酪氨酸激酶抑制剂。
物化属性
外观与形状:灰白色固体
密度:1.36
折射率:1.65
颜色:白色至微黄至微绿黄色粉末
蒸汽密度:2.06X10-18 mm Hg at 25 deg C (est)
解离常数:pKa1 = 2.1; pKa2 = 5.4
PSA:97.62000
LOGP:6.50180
[1]. Weisberg E, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20.
[2]. Sako H, et al. Antitumor effect of the tyrosine kinase inhibitor Nilotinib on gastrointestinal stromal tumor (GIST) and Imatinib-resistant GIST cells. PLoS One. 2014 Sep 15;9(9):e107613.
[3]. Dervis Hakim G, et al. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. World J Gastroenterol. 2015 Nov 28;21(44):12576-85.
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