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Cardiogenol C hydrochloride

Cardiogenol C hydrochloride 671225-39-1
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产品信息
产品名称:Cardiogenol C hydrochloride 纯度:98% min
CAS NO:671225-39-1 溶解度:
分子式:C13H17ClN4O2 包装:可按客户要求包装
分子量:296.753 贮存:-20℃
质量控制
备注说明

Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM. Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells.


英文别名:

2-[[2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl]amino]ethanol


物化属性:

密度:1.305

沸点:520.3°C at 760 mmHg

折射率:1.667

闪光点:268.5°C

PSA:79.30000

LOGP:2.58100

参考文献

1: Ivanyuk D, Budash G, Zheng Y, Gaspar JA, Chaudhari U, Fatima A, Bahmanpour S, Grin VK, Popandopulo AG, Sachinidis A, Hescheler J, Šarić T. Ascorbic Acid-Induced Cardiac Differentiation of Murine Pluripotent Stem Cells: Transcriptional Profiling and Effect of a Small Molecule Synergist of Wnt/β-Catenin Signaling Pathway. Cell Physiol Biochem. 2015;36(2):810-30. doi: 10.1159/000430140. Epub 2015 May 22. PubMed PMID: 26021268.

2: Koley M, Mike AK, Heher P, Koenig X, Schön M, Schnürch M, Hilber K, Weitzer G, Mihovilovic MD. VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes. Medchemcomm. 2013 Aug 1;4(8):1189-1195. PubMed PMID: 25045463; PubMed Central PMCID: PMC4101245.

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