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多韦替尼乳酸盐Dovitinib(CHIR-258; TKI258) lactate是高效的成纤维细胞生长因子受体3(FGFR3)抑制剂,IC50值为5 nM。
中文别名:
多韦替尼乳酸盐无水物
物化属性:
PSA:151.57000
LOGP:2.58040
[1]. Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood. 2005, 105(7), 2941-2948.
[2]. Huynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56(3), 595-601.
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