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西达本胺杂质 HDAC-IN-7 (Chidamide impurity) 是 Chidamide 的一种杂质。Chidamide 是一种有效的,可口服的 HDAC 第 I 类 HDAC1/2/3 和第 IIb 类 HDAC10 抑制剂。
中文别名:
西达苯胺杂质; N-(2-氨基-5-氟苯基)-4-(N-(3-吡啶丙烯酰基)氨甲基)苯甲酰胺; 爱谱沙杂质
物化属性:
PSA:97.11000
LOGP:4.42990
[1]. Ning ZQ, et al. Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother Pharmacol. 2012 Apr;69(4):901-9.
[2]. Gong K, et al. CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells. Biochem J. 2012 May 1;443(3):735-46.
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