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利那洛肽Linaclotide是一种有效和选择性的鸟苷酸环化酶C激动剂;开发用于治疗便秘型肠易激综合症 (IBS-C) 和慢性便秘。
[1]. Bryant AP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 8;86(19-20):760-5.
[2]. Love BL, et al. Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome. Am J Health Syst Pharm. 2014 Jul 1;71(13):1081-91.
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