0576-88813233
Galeterone (TOK-001) 是一种多功能的抗雄激素,是 CYP17 抑制剂,在去势抵抗性前列腺癌中,IC50 为 47 nM。
物化属性:
密度:1.28
熔点:189-190 °C
沸点:564.5 °C at 760 mmHg
闪光点:295.2 °C
[1]. Bruno RD, et al. Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.Steroid
[2]. DeVore NM, et al. Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.Nature. 2012 Jan 22;482(7383):116-9.
版权所有 Copyright(C) 2018-2024 台州市科瑞生物技术有限公司