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伊卢多啉 Eluxadoline

伊卢多啉 Eluxadoline 864821-90-9
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产品信息
产品名称:伊卢多啉 Eluxadoline 纯度:98% min
CAS NO:864821-90-9 溶解度:
分子式:C32H35N5O5 包装:可按客户要求包装
分子量:569.651 贮存:-20℃
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备注说明

Eluxadoline, also known as JNJ-27018966, is a novel, orally-active drug approved for the treatment of diarrhea and abdominal pain in individuals with diarrhea-predominant irritable bowel syndrome (IBS-D). It was approved for use by the United States Food and Drug Administration on May 27, 2015. Eluxadoline is a μ- and κ-opioid receptor agonist and δ-opioid receptor antagonist that acts locally in the enteric nervous system, possibly decreasing adverse effects on the central nervous system. This product is discintinued (DEA Schedule IV).



参考文献

1: Gohil K. Pharmaceutical Approval Update. P T. 2015 Aug;40(8):493-532. PubMed PMID: 26236136; PubMed Central PMCID: PMC4517530.

2: Hornby PJ. Drug discovery approaches to irritable bowel syndrome. Expert Opin Drug Discov. 2015 Aug;10(8):809-24. doi: 10.1517/17460441.2015.1049528. PubMed PMID: 26193876.

3: Garnock-Jones KP. Eluxadoline: First Global Approval. Drugs. 2015 Jul;75(11):1305-10. doi: 10.1007/s40265-015-0436-4. PubMed PMID: 26149369.

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